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KMID : 0043320120350010059
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Archives of Pharmacal Research
2012 Volume.35 No. 1 p.59 ~ p.68
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Novel 4-(4-substituted-thiazol-2-ylamino)-N-(pyridin-2-yl)-benzenesulfonamides as cytotoxic and radiosensitizing agents
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Ghorab Mostafa M.
Ragab Fatma A.
Heiba Helmy I.
Agha Hebaallah M.
Nissan Yassin M.
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Abstract
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A series of novel 4-(4-substituted-thiazol-2-ylamino)-N-(pyridin-2-yl) benzene-sulfonamides were synthesized and screened for their cytotoxic activity against human breast cancer cell line (MCF-7). Compounds 6, 7, 9, 10, 11, and 14 displayed significant activity against MCF-7 when compared to doxorubicin, which was used as a reference drug. The synergistic effect of Gamma radiation for the most active derivatives 7, 9, and 11 was also studied and their IC50 values markedly decreased to 11.9 μM, 11.7 μM, and 11.6 μM, respectively.
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KEYWORD
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Sulfonamides, Thiazoles, Cytotoxic, Radiosensetizing activities
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